Quiz: BRCA Mutations Across Cancer Types

Test your understanding of BRCA1/2 mutations, their role in cancer risk, prevention strategies, and therapeutic implications as presented by Dr. Judith van Manya.

Health mixed 8 Questions Video Quiz

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Q1 Beginner 1 pts

According to the video, what is the estimated prevalence of BRCA mutations in the general population? Video Reference:
"germline mutations in these genes are relatively rare it is estimated that their prevalence in the p..."

Timestamp: 1:00

1 out of 200-400 individuals 1 out of 40 individuals 1 out of 1000 individuals 1 out of 50 individuals

Q2 Intermediate 2 pts

What is the cumulative risk of breast cancer by age 80 for BRCA1 carriers according to the video? Video Reference:
"the cumulative risk of breast cancer in brca1 carriers is 40 percent at age 50 and 72% at age 18..."

Timestamp: 2:00

72% 68% 40% 35%

Q3 Intermediate 2 pts

In Ashkenazi ancestry individuals, what is the prevalence of BRCA mutations according to the speaker? Video Reference:
"this prevalence is higher in certain groups such as individuals of Ashkenazi ancestry where the prev..."

Timestamp: 1:30

2.5% (1 in 40) 1% (1 in 100) 5% (1 in 20) 0.5% (1 in 200)

Q4 Advanced 3 pts

What percentage of invasive epithelial non-mucinous ovarian cancer patients might have a germline BRCA1 or BRCA2 mutation? Video Reference:
"between 8 to 18 percent of women with invasive epithelial non-musicians ovarian cancer might have a ..."

Timestamp: 2:30

8-18% 2-5% 4-6% 1-2%

Q5 Beginner 1 pts

At what age does the video recommend starting breast MRI surveillance for women with BRCA mutations? Video Reference:
"women are recommended to undergo breast MRI from the age of 25 and add a mammogram at age 30 on a ye..."

Timestamp: 3:00

25 years 30 years 35 years 40 years

Q6 Intermediate 2 pts

True or False: According to the video, prophylactic mastectomy has been associated with a 90% or more breast cancer risk reduction in BRCA mutation carriers. Video Reference:
"prophylactic mastectomy has also been associated with a 90% or more breast cancer risk reduction..."

Timestamp: 3:20

True

False

Q7 Advanced 3 pts

What are the two main types of targeted therapies mentioned for BRCA-deficient cancers? Video Reference:
"cancer cells with BRCA mutations lead to homologous recombination repair deficiency and are more sen..."

Timestamp: 4:00

Select all correct answers

Platinum agents PARP inhibitors Immunotherapy Hormone therapy

Q8 Intermediate 2 pts

What is the recommended age for bilateral salpingo-oophorectomy in BRCA1 carriers according to the video? Video Reference:
"bilaterals helping cover ectomy is recommended usually at age 40 and in brca2 carriers at around age..."

Timestamp: 3:40

Age 40 Age 45 Age 50 Age 35

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Quiz: BRCA Mutations Across Cancer Types

According to the video, what is the estimated prevalence of BRCA mutations in the general population? Video Reference: "germline mutations in these genes are relatively rare it is estimated that their prevalence in the p..." Timestamp: 1:00

What is the cumulative risk of breast cancer by age 80 for BRCA1 carriers according to the video? Video Reference: "the cumulative risk of breast cancer in brca1 carriers is 40 percent at age 50 and 72% at age 18..." Timestamp: 2:00

In Ashkenazi ancestry individuals, what is the prevalence of BRCA mutations according to the speaker? Video Reference: "this prevalence is higher in certain groups such as individuals of Ashkenazi ancestry where the prev..." Timestamp: 1:30

What percentage of invasive epithelial non-mucinous ovarian cancer patients might have a germline BRCA1 or BRCA2 mutation? Video Reference: "between 8 to 18 percent of women with invasive epithelial non-musicians ovarian cancer might have a ..." Timestamp: 2:30

At what age does the video recommend starting breast MRI surveillance for women with BRCA mutations? Video Reference: "women are recommended to undergo breast MRI from the age of 25 and add a mammogram at age 30 on a ye..." Timestamp: 3:00

True or False: According to the video, prophylactic mastectomy has been associated with a 90% or more breast cancer risk reduction in BRCA mutation carriers. Video Reference: "prophylactic mastectomy has also been associated with a 90% or more breast cancer risk reduction..." Timestamp: 3:20

What are the two main types of targeted therapies mentioned for BRCA-deficient cancers? Video Reference: "cancer cells with BRCA mutations lead to homologous recombination repair deficiency and are more sen..." Timestamp: 4:00

What is the recommended age for bilateral salpingo-oophorectomy in BRCA1 carriers according to the video? Video Reference: "bilaterals helping cover ectomy is recommended usually at age 40 and in brca2 carriers at around age..." Timestamp: 3:40